Effects of PBBs on cattle. III. Target organ modification as shown by renal function and liver biochemistry

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Effects of PBBs on cattle. III. Target organ modification as shown by renal function and liver biochemistry

Efforts were made to more clearly delineate target organs and mechanisms of toxicity for PBBs in cattle. Methods were developed to obtain sequential liver biopsies on bovine heifers which yield 0.5 to 1.0 g of tissue. PBB was fed at a dose of 250 mg/head/day to Holstein heifers for 202 days. This dose produced no clinical signs of toxicity in any of the heifers, yet this produced tissue PBB con...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1978

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.7823119